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August 23th, 2005 | Issue 27 |
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High Cholesterol Speeds Growth Of Cancer
High blood cholesterol levels accelerate the growth of prostate tumors, new laboratory research reports.*
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PRITIKIN'S APOLOGIES
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Led by Dr. Michael Freeman at Children’s Hospital Boston, scientists injected human prostate cancer cells into mice. They fed half the mice a high-fat, high-cholesterol diet. In these mice, blood cholesterol levels shot up, and, observed the scientists, cholesterol accumulated in the outer membranes of the tumor cells, activating a chemical “cell-survival” pathway called Akt, which has been found to help tumors survive and thrive.
Six weeks after the tumor cells were injected, the incidence of tumors more than doubled in the mice on the high-fat, high-cholesterol diets. Activation of Akt, Dr. Freeman and his team concluded, enabled the tumor cells to resist chemical cues that trigger apoptosis (programmed cell death).
These new findings echo previous research on populations that have linked prostate cancer with high levels of cholesterol in the blood as well as with Western diets high in cholesterol- and saturated fat-rich foods like red meat and full-fat dairy products.
They also mirror research from UCLA scientist Dr. James Barnard. When Dr. Barnard and his team mixed blood samples of men on a typical high-fat, high-cholesterol American diet in dishes with prostate cancer cells, the cancer cells...
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Pritikin Perspective - Healthy Living Made Easier
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Editor/Writer: Eugenia Killoran.
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