Diet & Exercise Best at Reversing Metabolic Syndrome

Lifestyle changes are significantly more effective than drugs for preventing the Metabolic Syndrome, a cluster of problems that can lead to diabetes and cardiovascular disease, according to a large federally-funded study of 3,234 men and women.

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Lifestyle changes are significantly more effective than drugs for reversing Metabolic Syndrome.

Lifestyle changes are significantly more effective than drugs for preventing and reversing Metabolic Syndrome, a cluster of problems that can lead to diabetes and cardiovascular disease, according to a large federally-funded study of 3,234 men and women.¹

Lead investigator Dr. Trevor Orchard at the University of Pittsburgh and colleagues called the effects of lifestyle change “dramatic.”

Diabetes Prevention Program

At the beginning of the study, named the Diabetes Prevention Program, none of the subjects had type 2 diabetes, but they were on their way. All were struggling with high blood sugar, and more than half were diagnosed with the Metabolic Syndrome, which means they had three of more of the following five problems: abdominal obesity, high triglycerides, low HDL good cholesterol, high blood pressure, and elevated fasting blood sugar.  

The scientists randomly divided the 3,234 pre-diabetics into three different groups. The first group was given the anti-diabetes drug metformin (brand name is Glucophage). The second received a placebo.

The third group received intensive lifestyle intervention – 16 educational workshops plus several refresher sessions, all centered on “losing weight through physical activity and a healthy low-calorie, low-fat diet,” wrote the authors.

Healthful Carbohydrates, Low In Fat

The lifestyle group was taught to be a “fat detective” and steer away from high-calorie/high-fat foods. The optimal diet, the workshops emphasized, was one rich in healthful carbohydrates like vegetables, fruits, and fiber-filled whole grains, supplemented with modest servings of lean protein like nonfat dairy foods and lean meat.

Class titles included: “Move Those Muscles,” “Vegetarian Food Options,” “Healthy Eating On the Town,” “Healthful, Low-Fat Cooking,” “Managing Binges,” and “Staying Motivated.” (Yes, the education closely resembled the education received at the Pritikin Longevity Center.)

The two key goals of the lifestyle intervention approach were: 1) Maintain a weight reduction of at least 7%, and 2) Engage in physical activity of moderate activity, such as brisk walking, for at least 2-1/2 hours a week.

Lifestyle More Than Twice As Effective As Drugs

At the three-year follow-up, the incidence of Metabolic Syndrome was reduced by 41% in the lifestyle group and by 17% in the metformin group compared with the placebo group. Healthy diet and regular exercise, in short, were nearly 2-1/2 times more effective than medication at getting rid of the Metabolic Syndrome.

These data, concluded Dr. Orchard and his team, demonstrate the “dramatic effect of lifestyle … The beneficial effect of lifestyle intervention on components other than glucose level is particularly encouraging and provides important evidence of the value of this approach to those with blood pressure, weight, and lipid disturbances in general.”

The inferior effect of medication, the authors continued, “underscores the preferential value of lifestyle as the initial approach to prevention of the Metabolic Syndrome and its cardiovascular complications.”

Reversing Metabolic Syndrome and Preventing Type 2 Diabetes

These conclusions are in line with an earlier study on the 3,234 men and women of the Diabetes Prevention Program, which found that lifestyle intervention was about twice as effective as drugs at preventing those with impaired glucose tolerance from progressing to type 2 diabetes. ²

Within three years, 29% of the subjects in the placebo group and 22% in the metformin group had developed diabetes. Among the healthy eaters and exercisers, just 14% had become diabetics.

Getting Free Of Medications

With proper dietary intervention and regular exercise, blood sugar levels fall so dramatically, studies on the Pritikin Program have found, that many type 2 diabetics no longer require anti-diabetes medications. In a newly published meta-analysis of 284 diabetics who attended the Pritikin Longevity Center, 74% left Pritikin no longer needing drugs to control their blood sugar. ³

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¹ Annals of Internal Medicine, 2005; 142: 661.
² New England Journal of Medicine, 2002; 346: 393.
³ Journal of Applied Physiology, 2005; 98: 3.

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Are you taking or considering a medication for weight loss?

Combining the Pritikin Program with Semaglutide or other weight loss medications could potentially speed up weight loss, reduce side effects, preserve lean body mass, and support long-term metabolic health.